Folliculitis decalvans: a multicentre review of 82 patients
Identifieur interne : 000F57 ( Main/Exploration ); précédent : 000F56; suivant : 000F58Folliculitis decalvans: a multicentre review of 82 patients
Auteurs : S. Va Alván [Espagne] ; A. M. Molina-Ruiz [Espagne] ; P. Fernández-Crehuet [Espagne] ; A. R. Rodrigues-Barata [Espagne] ; S. Arias-Santiago [Espagne] ; C. Serrano-Falc N [Espagne] ; A. Martorell-Calatayud [Espagne] ; D. Barco [Espagne] ; B. Pérez [Espagne] ; S. Serrano [Espagne] ; L. Requena [Espagne] ; R. Grimalt [Espagne] ; J. Paoli [Suède] ; P. Jaén [Espagne] ; F. M. Camacho [Espagne]Source :
- Journal of the European Academy of Dermatology and Venereology [ 0926-9959 ] ; 2015-09.
Abstract
Background: Folliculitis decalvans (FD) is a rare neutrophilic scarring alopecia that represents a therapeutic challenge for dermatologists. Objective: To describe the epidemiology, comorbidities, clinical presentation, diagnostic findings and therapeutic options in a large series of patients with FD. Methods: This retrospective multicentre review includes patients diagnosed with FD based on clinical and histopathologic findings. The clinical severity was determined by the maximum diameter of the largest alopecic patch (slight: <2 cm, moderate: 2–4.99 cm, severe: 5 cm or more). Response to therapy was assessed as improvement, worsening or stabilization depending on the clinical symptoms (pruritus and trichodynia), inflammatory signs (erythema, pustules and crusts) and the extension of the alopecic patch. Results: Overall, 82 patients (52 males and 30 females) with a mean age of 35 years were included. No significant comorbidities were present. A family history was present in three males. Severe FD was observed in 17 patients (21%). The independent factors associated with severe FD after multivariate analysis were: onset of FD before 25 years of age and presence of pustules. Oral antibiotics (tetracyclines and the combination of clindamycin and rifampicin) improved 90% and 100% of the patients, with a mean duration of response of 4.6 and 7.2 months respectively. Conclusions: The onset of FD before 25 years of age and the presence of pustules within the alopecic patch were associated with severe FD. Tetracyclines and the combination of clindamycin and rifampicin were the most useful treatments.
Url:
DOI: 10.1111/jdv.12993
Affiliations:
- Espagne, Suède
- Andalousie, Catalogne, Communauté de Madrid
- Barcelone, Grenade (Espagne), Madrid
- Université de Grenade
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Fernández-Crehuet</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Alto Guadalquivir de Andújar, Jaén</wicri:regionArea><wicri:noRegion>Jaén</wicri:noRegion></affiliation></author><author><name sortKey="Rodrigues Arata, A R" sort="Rodrigues Arata, A R" uniqKey="Rodrigues Arata A" first="A. R." last="Rodrigues-Barata">A. R. Rodrigues-Barata</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Grupo Pedro Jaén, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Arias Antiago, S" sort="Arias Antiago, S" uniqKey="Arias Antiago S" first="S." last="Arias-Santiago">S. 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Paoli</name><affiliation wicri:level="1"><country xml:lang="fr">Suède</country><wicri:regionArea>Sahlgrenska University Hospital, Gothenburg</wicri:regionArea><wicri:noRegion>Gothenburg</wicri:noRegion></affiliation></author><author><name sortKey="Jaen, P" sort="Jaen, P" uniqKey="Jaen P" first="P." last="Jaén">P. Jaén</name><affiliation wicri:level="3"><country xml:lang="fr">Espagne</country><wicri:regionArea>Hospital Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Camacho, F M" sort="Camacho, F M" uniqKey="Camacho F" first="F. M." last="Camacho">F. M. Camacho</name><affiliation wicri:level="1"><country xml:lang="fr">Espagne</country><wicri:regionArea>Virgen Macarena, Sevilla</wicri:regionArea><wicri:noRegion>Sevilla</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of the European Academy of Dermatology and Venereology</title><title level="j" type="alt">JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY</title><idno type="ISSN">0926-9959</idno><idno type="eISSN">1468-3083</idno><imprint><biblScope unit="vol">29</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1750">1750</biblScope><biblScope unit="page" to="1757">1757</biblScope><biblScope unit="page-count">8</biblScope><date type="published" when="2015-09">2015-09</date></imprint><idno type="ISSN">0926-9959</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0926-9959</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background: Folliculitis decalvans (FD) is a rare neutrophilic scarring alopecia that represents a therapeutic challenge for dermatologists. Objective: To describe the epidemiology, comorbidities, clinical presentation, diagnostic findings and therapeutic options in a large series of patients with FD. Methods: This retrospective multicentre review includes patients diagnosed with FD based on clinical and histopathologic findings. The clinical severity was determined by the maximum diameter of the largest alopecic patch (slight: <2 cm, moderate: 2–4.99 cm, severe: 5 cm or more). Response to therapy was assessed as improvement, worsening or stabilization depending on the clinical symptoms (pruritus and trichodynia), inflammatory signs (erythema, pustules and crusts) and the extension of the alopecic patch. Results: Overall, 82 patients (52 males and 30 females) with a mean age of 35 years were included. No significant comorbidities were present. A family history was present in three males. Severe FD was observed in 17 patients (21%). The independent factors associated with severe FD after multivariate analysis were: onset of FD before 25 years of age and presence of pustules. Oral antibiotics (tetracyclines and the combination of clindamycin and rifampicin) improved 90% and 100% of the patients, with a mean duration of response of 4.6 and 7.2 months respectively. Conclusions: The onset of FD before 25 years of age and the presence of pustules within the alopecic patch were associated with severe FD. Tetracyclines and the combination of clindamycin and rifampicin were the most useful treatments.</div></front></TEI><affiliations><list><country><li>Espagne</li><li>Suède</li></country><region><li>Andalousie</li><li>Catalogne</li><li>Communauté de Madrid</li></region><settlement><li>Barcelone</li><li>Grenade (Espagne)</li><li>Madrid</li></settlement><orgName><li>Université de Grenade</li></orgName></list><tree><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Va Alvan, S" sort="Va Alvan, S" uniqKey="Va Alvan S" first="S." last="Va Alván">S. Va Alván</name></region><name sortKey="Arias Antiago, S" sort="Arias Antiago, S" uniqKey="Arias Antiago S" first="S." last="Arias-Santiago">S. Arias-Santiago</name><name sortKey="Barco, D" sort="Barco, D" uniqKey="Barco D" first="D." last="Barco">D. Barco</name><name sortKey="Camacho, F M" sort="Camacho, F M" uniqKey="Camacho F" first="F. M." last="Camacho">F. M. Camacho</name><name sortKey="Fernandez Rehuet, P" sort="Fernandez Rehuet, P" uniqKey="Fernandez Rehuet P" first="P." last="Fernández-Crehuet">P. Fernández-Crehuet</name><name sortKey="Grimalt, R" sort="Grimalt, R" uniqKey="Grimalt R" first="R." last="Grimalt">R. Grimalt</name><name sortKey="Jaen, P" sort="Jaen, P" uniqKey="Jaen P" first="P." last="Jaén">P. Jaén</name><name sortKey="Martorell Alatayud, A" sort="Martorell Alatayud, A" uniqKey="Martorell Alatayud A" first="A." last="Martorell-Calatayud">A. Martorell-Calatayud</name><name sortKey="Molina Uiz, A M" sort="Molina Uiz, A M" uniqKey="Molina Uiz A" first="A. M." last="Molina-Ruiz">A. M. Molina-Ruiz</name><name sortKey="Perez, B" sort="Perez, B" uniqKey="Perez B" first="B." last="Pérez">B. Pérez</name><name sortKey="Requena, L" sort="Requena, L" uniqKey="Requena L" first="L." last="Requena">L. Requena</name><name sortKey="Rodrigues Arata, A R" sort="Rodrigues Arata, A R" uniqKey="Rodrigues Arata A" first="A. R." last="Rodrigues-Barata">A. R. Rodrigues-Barata</name><name sortKey="Serrano Alc N, C" sort="Serrano Alc N, C" uniqKey="Serrano Alc N C" first="C." last="Serrano-Falc N">C. Serrano-Falc N</name><name sortKey="Serrano, S" sort="Serrano, S" uniqKey="Serrano S" first="S." last="Serrano">S. Serrano</name><name sortKey="Va Alvan, S" sort="Va Alvan, S" uniqKey="Va Alvan S" first="S." last="Va Alván">S. Va Alván</name></country><country name="Suède"><noRegion><name sortKey="Paoli, J" sort="Paoli, J" uniqKey="Paoli J" first="J." last="Paoli">J. Paoli</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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